Tools for Single-Cell Biology
Single-cell biology is a quickly growing field. We aim to develop tools based on micro and nanoscale technologies to access, manipulate and analyze single cells. We work on three sub-projects as described bellow. Hollow nanowires are used to penetrate cells to extract or inject chemicals. Sorting devices are developed to ultimately be able to sort out single cells of interest with a label-free approach. Nanochannels are used to stretch single molecules of DNA and directly visualize the DNA for genetic analysis.
Hollow nanowires are used as small injection needles for transportation of molecules into single cells.
Microfluidic devices based on regular post arrays are made for label-free sorting of particles and molecules.
Fundamental questions as well as genetic applications of DNA confined in nanochannels are pursued.
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